CURRENT ISSUE
September, 2020
No. 105 (9)
2024 Impact Factor: 7.9
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
EDITOR'S PICKS
Review Series On Indolent Lymphomas
Phase-II study of the new aza-anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas
Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children
Thrombophilias and adverse pregnancy outcome
The factor V HR2 haplotype and the risk of venous thrombosis: a meta-analysis
Letters to the Editor
Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children
ARTICLES IN THREE SENTENCES
Letters to the Editor
A rare beta-thalassaemia mutation (C-T) at position -90 of the beta-globin gene discovered in a Chinese family
Terminal erythroid maturation requires that the chaperone Heat Shock Protein 70 (HSP70) accumulates in the nucleus. This is inhibited in human β-thalassemia major erythroblasts due to HSP70 sequestration by free α-globin chains. This study demonstrated that treatment of β−thalassemic erythroblasts with an exportin-1 inhibitor increases the amount of nuclear HSP70 and improves their terminal differentiation.
Case Reports
Work-related acute leukemia and mucor mycosis in a boat-builder
The authors characterized the mutational profile of diffuse large B-cell lymphoma and evaluated the prognostic impact of somatic mutations in 499 patients. Only alterations in BCL2 were significantly associated with clinical outcome independently of cell of origin and clinical factors.
Letters to the Editor
Aggressive natural killer cell leukemia: clinical features and treatment outcome
This study analyzed the functional effects of abrogation of RAL, a member of the RAS superfamily of small GTPases, in myeloma cell lines and found that it is a critical mediator of survival independently of oncogenic RAS. Combining RAL depletion with clinically relevant anti-myeloma agents led to enhanced rates of cell death. Thus, RAL represents a potential therapeutic target in its own right.
Case Reports
Littoral cell angioma of the spleen in a patient with severe aplastic anaemia
This study investigated 4682 babies with sickle cell disease contributing to 35291 person-years of follow-up. Death incidence rate was 0.16 per 100 person-years, with infection as the leading cause of death and acute splenic sequestration as the second cause. Better empowerment of families and closer monitoring of younger patients are required to further decrease mortality rates.
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